Identification of Alpelisib (BYL 719) as a Potential Treatment for Endometrial Cancers
The study compared Alpelisib activity in 388 patient-derived specimens isolated from surgical biopsies to examine disease-specific activity and found uterine cancers to be significantly more sensitive than other tumor types.
- The study compared Alpelisib activity in 388 patient-derived specimens isolated from surgical biopsies to examine disease-specific activity and found uterine cancers to be significantly more sensitive than other tumor types.
- The EVA/PCD results confirm these alterations to be therapeutic targets for Alpelisib with these PIK3CA-related tumors proving to be the most sensitive.
- Additional analyses compared the activity of Alpelisib with other classes of drugs and explored novel drug combinations for activity and synergy.
- Caught early it can be cured with surgery, but the treatment of advanced disease remains an unmet need in contemporary medical oncology.