Researchers Assemble Nine Synthetic Yeast Chromosomes
NEW YORK, Nov. 8, 2023 /PRNewswire/ -- A team led by researchers at NYU Langone Health has built nine new synthetic yeast chromosomes, swapping out a key organism's genetic material for engineered replacements.
- NEW YORK, Nov. 8, 2023 /PRNewswire/ -- A team led by researchers at NYU Langone Health has built nine new synthetic yeast chromosomes, swapping out a key organism's genetic material for engineered replacements.
- In 2014, Sc2.0 reported the building of the first synthetic yeast chromosome (synthetic chromosome 3, or synIII), and five additional chromosomes (synII, synV, synVI, synX, and synXII) followed by 2017.
- The team's challenge now, after having assembled all 16 synthetic yeast chromosomes, is to consolidate them into a single living yeast strain, the authors said.
- Dr. Zhao and colleagues just published in Cell their significant progress on this front by incorporating 6.5 synthetic yeast chromosomes into one yeast cell using an established, but tedious method.