Tears

Nintendo Download: Days of Present Past

Retrieved on: 
Thursday, January 18, 2024

Help Ashley Mizuki Robins solve riddles, gather clues and investigate the traces of the past to uncover the true fates of her parents.

Key Points: 
  • Help Ashley Mizuki Robins solve riddles, gather clues and investigate the traces of the past to uncover the true fates of her parents.
  • Another Code: Recollection launches on Jan. 19 and will be available in Nintendo eShop or in the My Nintendo Store on Nintendo.com.
  • Download the free demo featuring the game’s first chapter from Nintendo eShop today, then carry over your progress to the full game after purchasing.
  • Nintendo eShop sales on Nintendo Switch:
    Also new this week in Nintendo eShop on Nintendo Switch:

MAVTV Premieres New Episode of Original Docuseries "THE LIFE" Featuring Antron Brown, Three-Time NHRA Champion

Retrieved on: 
Wednesday, January 24, 2024

The upcoming episode shines the spotlight on Antron Brown, a three-time NHRA Top Fuel world champion and one of the most exceptional athletes in the world of motorsports.

Key Points: 
  • The upcoming episode shines the spotlight on Antron Brown, a three-time NHRA Top Fuel world champion and one of the most exceptional athletes in the world of motorsports.
  • "It's an incredible experience to share my story with the MAVTV audience.
  • He formed his own team, AB Motorsports, which made an impressive NHRA debut in 2022, finishing ranked No.
  • Don't miss "THE LIFE: Antron Brown" premiering only on MAVTV on Thursday, Feb. 1 at 8 p.m. ET/PT, for an in-depth look at the life of a legend in the world of motorsports.

Heron Therapeutics Announces FDA Approval of ZYNRELEF® Indication Expansion to Include Additional Orthopedic and Soft Tissue Procedures

Retrieved on: 
Wednesday, January 24, 2024

SAN DIEGO, Jan. 23, 2024 /PRNewswire/ -- Heron Therapeutics, Inc. (Nasdaq: HRTX), a commercial-stage biotechnology company, today announced that the U.S. Food and Drug Administration (the "FDA") has approved its supplemental New Drug Application ("NDA") for ZYNRELEF® (bupivacaine and meloxicam) extended-release solution to expand the indication for soft tissue and orthopedic surgical procedures including foot and ankle, and other procedures in which direct exposure to articular cartilage is avoided. ZYNRELEF was previously approved for foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures in adults.

Key Points: 
  • ZYNRELEF was previously approved for foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures in adults.
  • This expanded indication for ZYNRELEF will now cover an estimated 13 million procedures annually, an estimated increase of 86% over prior indicated procedures.
  • To obtain this labeling expansion, Heron successfully conducted studies for cesarean section, spinal surgery, augmentation mammoplasty, and total shoulder arthroplasty.
  • The most common side effects of ZYNRELEF are soft tissue procedures: vomiting and orthopedic procedures: constipation and headache.

Learning Without Tears Unveils Handwriting Without Tears C2025: Elevating Literacy Education with Science-Backed Innovations

Retrieved on: 
Tuesday, January 23, 2024

GAITHERSBURG, Md., Jan. 23, 2024 /PRNewswire-PRWeb/ -- On National Handwriting Day, Learning Without Tears, a leading early education company renowned for its unique teaching and learning approach, announces the latest evolution of Handwriting Without Tears C2025. Handwriting Without Tears C2025 retains its proven and beloved format, now with added content, features, and enhancements.

Key Points: 
  • GAITHERSBURG, Md., Jan. 23, 2024 /PRNewswire-PRWeb/ -- On National Handwriting Day, Learning Without Tears , a leading early education company renowned for its unique teaching and learning approach, announces the latest evolution of Handwriting Without Tears C2025 .
  • Handwriting Without Tears C2025 retains its proven and beloved format, now with added content, features, and enhancements.
  • Handwriting Without Tears C2025, a dedicated TK-6 program grounded in the science of reading and handwriting, provides a compelling solution for essential literacy skills.
  • Key features of Handwriting Without Tears C2025 include:
    A dedicated print and digital handwriting solution driven by science.

Healing Heel Pain: Researchers from Sahmyook University Explore the Use of Local Vibration in Plantar Fasciitis Treatment

Retrieved on: 
Thursday, January 18, 2024

SEOUL, South Korea, Jan. 18, 2024 /PRNewswire/ -- Plantar fasciitis (PF) is a common musculoskeletal, inflammatory condition, characterized by severe pain in the heel of the foot, to the extent that it limits day-to-day activities. The plantar fascia ligament, a fibrous connecting tissue, supports the arch of the foot and functions as a shock absorber, similar to modern-day car suspension systems. With increased activity, the ligament can experience tears and damage, leading to the development of PF.

Key Points: 
  • Treatment for PF includes pain management through anti-inflammatory drugs, stretching exercises, night-splint therapy, steroidal medications, and extracorporeal shock wave therapy (ESWT).
  • Interestingly, their study revealed the combination of local vibration and extra-corporeal shock therapy as an effective approach for treating chronic plantar fasciitis.
  • One group received a combination of local vibration (LV) and ESWT, while the other group underwent ESWT alone.
  • Title of original paper: Effects of Local Vibration Combined with Extracorporeal Shock Wave Therapy in Plantar Fasciitis: A Randomized Controlled Trial

Yumna Kassab's impressionistic novel Politica considers moral dilemmas and harsh choices in a time of war

Retrieved on: 
Wednesday, January 17, 2024

Politica is the fourth novel by Yumna Kassab, who has made a significant impact on the Australian literary scene since the publication of her debut novel The House of Youssef in 2019.

Key Points: 
  • Politica is the fourth novel by Yumna Kassab, who has made a significant impact on the Australian literary scene since the publication of her debut novel The House of Youssef in 2019.
  • Politica is written in Kassab’s now signature polyphonic style.
  • Set in a small community, the novel is sparsely written, with minimal description of character, place or historical moment.
  • Politica achieves its impressionistic effects through quirky vignettes, poetry, fable, gnomic aphorisms, and arguments between conservative forces and those seeking to redefine their values.
  • Some of the characters are resistance leaders and their heirs; others are ordinary people with everyday aspirations.
  • Accept the political as the only authentic option or seek the consolations of private life?
  • Politica has allegorical ambitions, so these dilemmas cannot be resolved by referring to a describable geopolitical reality.
  • The novel spans decades, yet no particular enemy or threat can be consistently identified, nor does it identify the nation in which it is set.
  • idolise death over life […] Such is the tendency of one who has not yet learned to live.


Read more:
Colonial and nationalist myths are recast in Yumna Kassab's Australiana

A moral project

  • This is of crucial importance when Arab and Muslim political movements, including that of the Palestinians, are relentlessly delegitimised and dehumanised.
  • Politica wants to show what a resistance movement might look like from the side of the oppressed.
  • The novel questions the total warfare the West now excuses as a drive for security.
  • Yet there is always a danger that a novel seeking to say something about politics will begin to moralise.
  • A war that began with noble ideals comes to resemble a plague laying waste to all who experience it.
  • It prefers bathos in a minor key to the ambitious scope of historical fiction, now an abundant postcolonial genre.


Ned Curthoys does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

The Legend of Zelda, Baldur’s Gate 3 and COCOON Lead Finalists for the 24th Annual Game Developers Choice Awards

Retrieved on: 
Tuesday, January 16, 2024

The finalists for the 24th Annual Game Developers Choice awards, the leading peer-based video game event celebrating the industry’s top games and developers, have been revealed.

Key Points: 
  • The finalists for the 24th Annual Game Developers Choice awards, the leading peer-based video game event celebrating the industry’s top games and developers, have been revealed.
  • The Game Developers Choice Awards are uniquely positioned as the leading video game awards that are nominated by, voted on, and decided by video game developers within the industry.
  • Any video game that was released and made publicly available during the 2023 calendar year is eligible for free nomination for the 2024 Game Developers Choice Awards.
  • As in years past, the Game Developers Choice Awards will be live-streamed alongside the Independent Games Festival Awards on the official GDC Twitch channel .

What if every germ hit you at the exact same time? An immunologist explains

Retrieved on: 
Tuesday, January 16, 2024

What would happen if all the diseases in the world hit us at the exact same time?

Key Points: 
  • What would happen if all the diseases in the world hit us at the exact same time?
  • – Gabriella, age 12, Irving, Texas
    What would happen if all the diseases in the world hit us at the exact same time?
  • – Gabriella, age 12, Irving, Texas When I was younger, I would watch “Batman” on my black-and-white television after school.
  • In fact, sometimes fighting off one enemy can leave a hole in your defenses that another opportunistic pathogen can take advantage of.

BAM! Understanding the rivals

  • The potential bad guys include cancer cells and dangerous microorganisms – including bacteria, viruses, fungi and more – that cause infections.
  • The immune system must also be careful not to damage healthy cells and beneficial microorganisms that live on and inside you.
  • Your skin, snot, saliva and tears form a critical first line of defense.
  • Gathering an army of immune cells to fight pathogens takes a lot of energy and makes you feel awful.

BOOM! Where are their weaknesses?

  • Pathogens have specific parts on their surfaces called pathogen associated molecular patterns, or PAMPs.
  • Because the same PAMP is present on many different pathogens, a strategy to combat one PAMP can defeat many pathogens.
  • There are molecules in cells all over your body that can recognize PAMPS and destroy anything those PAMPS are on.

SPLAT! Raising an army of defenders

  • When the virus that causes COVID-19 emerged in 2019, it was something people’s immune systems likely had never seen before.
  • The immune system makes many immune cells that are specific to antigens, or unique and recognizable parts of cancers and microorganisms, it hasn’t encountered before.
  • The DNA in each of these immune cells is different from the DNA in any other cell in your body.
  • Since pathogens can also multiply rapidly, clonal selection allows you to rapidly raise an army to fight them.
  • It would take a tremendous amount of energy and time to build an appropriate army against each microorganism all at once.


Joseph Larkin III receives funding from the Grayson Jockey Research Foundation, The National Institutes of Health, and industry.

Harrow Announces Availability of VEVYE® (Cyclosporine Ophthalmic Solution) 0.1%, the First and Only Cyclosporine-Based Product Indicated for Treating Both Signs and Symptoms of Dry Eye Disease

Retrieved on: 
Thursday, January 11, 2024

VEVYE, uniquely dispensed in a 10 microliter drop, is the first and only cyclosporine‑based product indicated for treating both the signs and symptoms of dry eye disease (DED).

Key Points: 
  • VEVYE, uniquely dispensed in a 10 microliter drop, is the first and only cyclosporine‑based product indicated for treating both the signs and symptoms of dry eye disease (DED).
  • In commenting on the announcement, Mark L. Baum, Chairman and Chief Executive Officer of Harrow, said, “We are thrilled to announce the availability of VEVYE for our customers and their patients.
  • VEVYE is powered by the unique combination of the reliable and trusted active ingredient, cyclosporine, and a water-free semifluorinated alkane delivery vehicle, perfluorobutylpentane.
  • In addition, 92% of this patient population remains un- or under-treated due to limited efficacy and poor tolerability of existing prescription and non-prescription choices.4

Made You Look! Introducing the Most Expensive Ice Cream Bars in the World at DOOZEE Bespoke Ice Cream Bar

Retrieved on: 
Wednesday, January 10, 2024

KEY WEST, Fla., Jan. 10, 2024 /PRNewswire/ -- When one thinks of 'luxury goods,' what comes to mind? Bags, diamonds, watches, designer clothes — but lo and behold, one Key West ice cream bar is serving up ice cream bars that are so exclusive, luxurious, and expensive that they may even make a dent in the projected $540.07 Billion 2028 luxury goods market. DOOZEE Bespoke Ice Cream Bar has launched the most expensive ice cream bar in the world!

Key Points: 
  • Key West, DOOZEE Bespoke Ice Cream Bar is serving up the most expensive and luxurious ice cream bars that have even the most opulent turning their heads.
  • DOOZEE Bespoke Ice Cream Bar has launched the most expensive ice cream bar in the world!
  • Rather, they will find a DOOZEE Bespoke Ice Cream Bar at 123 Duval St. that will help dry their tears and provide a once-in-a-lifetime opportunity to purchase the most expensive ice cream bar in the world.
  • To learn more about DOOZEE Bespoke Ice Cream Bar Shop, please visit: doozeebar.com