Lupus

Re-engineering Immune Cells Opens Door to Promising Therapy for Lupus Kidney Inflammation

Retrieved on: 
Tuesday, February 6, 2024

NEW YORK, Feb. 6, 2024 /PRNewswire/ -- Research featured in Nature Communications highlights a novel approach that re-engineers a person's own immune cells to suppress the overactive immune system that occurs in lupus nephritis, a serious and potentially life-threatening inflammation of the kidneys. With funding in part from the Lupus Research Alliance (LRA), associate professor Joshua Ooi, Ph.D. and his team at the Centre for Inflammatory Disease, Monash Health in Australia, developed an innovative method that could enable multiple targeted therapies not only for lupus but other autoimmune diseases as well.

Key Points: 
  • T cells direct the immune system's response to potential threats by identifying and attacking harmful invaders like viruses and bacteria.
  • In healthy individuals, a specific type of T cells called T regulatory cells (Tregs) prevent the immune system from continuing to react once an infection is cleared.
  • Earlier LRA funding allowed my team to pursue the idea that patients' immune cells could be engineered to correct immune dysfunction.
  • The Lupus Innovation Award then gave us the ability to test the effectiveness of these patient-derived engineered cells in a model of disease."

Autoimmune Disease and Pregnancy: ISB Study Challenges Prevailing Wisdom, Unveils Nuances

Retrieved on: 
Wednesday, January 31, 2024

Key Points: 
  • View the full release here: https://www.businesswire.com/news/home/20240131144327/en/
    In a just-published study in the journal Lancet eClinical Health , researchers at the Institute for Systems Biology (ISB) and Providence showed nuanced pregnancy outcomes for pregnant individuals with autoimmune disease.
  • Each type of autoimmune disease is different, each person has their own medical history, and risk may change over the course of pregnancy.
  • This study highlights the importance of taking comorbidities into consideration,” said ISB Associate Professor Jennifer Hadlock, MD , who led the study.
  • “These results can help reshape discussions surrounding autoimmune disease and pregnancy, and bring fresh perspective to a traditionally understudied area in research,” Hadlock said.

Lupus Research Alliance 2023 Dr. William E. Paul Distinguished Innovator Award Granted to Yale School of Medicine Researcher Akiko Iwasaki, Ph.D.

Retrieved on: 
Tuesday, January 30, 2024

NEW YORK, Jan. 30, 2024 /PRNewswire/ -- The Lupus Research Alliance (LRA) is pleased to grant the 2023 Dr. William E. Paul Distinguished Innovator Award (DIA) to Akiko Iwasaki, Ph.D., Sterling Professor of Immunobiology at the Yale School of Medicine. Dr. Iwasaki will investigate a possible cause of lupus – remnants of ancient viruses that have been integrated into our genome called endogenous retroviruses. The DIA provides investigators up to $1 million over four years to explore bold, paradigm-shifting ideas that could lead to groundbreaking discoveries in lupus research.

Key Points: 
  • NEW YORK, Jan. 30, 2024 /PRNewswire/ -- The Lupus Research Alliance (LRA) is pleased to grant the 2023 Dr. William E. Paul Distinguished Innovator Award (DIA) to Akiko Iwasaki , Ph.D., Sterling Professor of Immunobiology at the Yale School of Medicine.
  • Dr. Iwasaki will investigate a possible cause of lupus – remnants of ancient viruses that have been integrated into our genome called endogenous retroviruses.
  • The DIA provides investigators up to $1 million over four years to explore bold, paradigm-shifting ideas that could lead to groundbreaking discoveries in lupus research.
  • With this award, we will probe the link between the immune system reacting to viruses within us as a possible trigger of lupus disease," commented Dr. Iwasaki.

There is overwhelming gender bias in the NDIS – and the review doesn’t address it

Retrieved on: 
Tuesday, January 30, 2024

The review acknowledges women with disability face barriers to access support and efforts to understand their experiences need to be accelerated.

Key Points: 
  • The review acknowledges women with disability face barriers to access support and efforts to understand their experiences need to be accelerated.
  • As part of review feedback, key disability organisations said a gender strategy was needed.
  • Yet the final recommendations remain largely silent on gender, despite overwhelming gender inequality in the NDIS.

To uphold women’s right to safety

  • Only three out of the 222 disability royal commission recommendations explicitly focus on women.
  • Read more:
    Unregistered NDIS providers are in the firing line – but lots of participants have good reasons for using them

To support women as participants, as well as carers

  • Women are also over-represented as carers for people with disability.
  • Half of all NDIS participants are children and nearly 90% of primary carers for children are women.
  • Women are highly successful advocates for their children.

To stop reproducing medical bias

  • NDIS assessments rely on evidence from health-care professionals, which means the NDIS likely reproduces the gender biases of the medical system.
  • How the NDIS review could help people with psychosocial disability

    Many chronic conditions experienced predominantly by women can have fluctuating symptoms.

  • These conditions – and others that get worse over time – can significantly escalate without appropriate daily living supports.

To close access gaps

  • The fresh NDIS review echoes previous reviews that found gaps and ambiguity between the NDIS and health systems.
  • New agreements with states announced prior to the review similarly lack attention to gender, so there is no assurance women trying to access support outside the NDIS won’t continue to face the same barriers.

More detailed data would be a good start

  • The cycle of applying and re-applying is a heavy administrative and emotional burden, disproportionately shouldered by women.
  • Collecting more detailed data about participants “disaggregated by gender and sexuality” is listed in the review’s recommendations.
  • Diana Piantedosi works for Women with Disabilities Victoria (WDV) and is also a member of the Victorian Disability Advisory Council (VDAC), Victorian NDIS Community Advisory Council (VCAC) and DFFH's LGBTIQA+ Disability Inclusion Expert Advisory Group.
  • Lena Molnar works for Women with Disabilities Victoria (WDV).

CORRECTION BY SOURCE: Solta Medical's Thermage(R) FLX and TR-4 Return Pad Receive Registration Certifications in China

Retrieved on: 
Monday, January 22, 2024

[See *Correction above: The TR-4 Return Pad is not approved for use by the U.S. Food & Drug Administration.]

Key Points: 
  • [See *Correction above: The TR-4 Return Pad is not approved for use by the U.S. Food & Drug Administration.]
  • "The approval of Thermage FLX, and the TR-4 return pad, marks a significant milestone for Solta Medical," Thomas J. Appio, Bausch Health Chief Executive Officer, said.
  • "The approval from NMPA means we are able to continue the momentum of the growth of Thermage in China," Jiny Kim, Senior Vice President, Solta Medical, said.
  • Ask your doctor for more information about Thermage FLX and see www.thermage.com for additional details.

Antibody Therapeutics Market Size to Grow USD 364180 Million by 2029 at a CAGR of 11% | Valuates Reports

Retrieved on: 
Sunday, January 21, 2024

Antibody Based Therapeutics Market is projected to reach USD 364180 Million in 2029, increasing from USD 175410 Million in 2022, with a CAGR of 11.0% during the period of 2023 to 2029.

Key Points: 
  • Antibody Based Therapeutics Market is projected to reach USD 364180 Million in 2029, increasing from USD 175410 Million in 2022, with a CAGR of 11.0% during the period of 2023 to 2029.
  • The medical community's rising acceptance of antibody therapies is partly due to their expanding applicability, particularly in cancer and autoimmune illnesses.
  • The market for antibody therapies is expanding due to the rising incidence of chronic illnesses worldwide.
  • The Market for Antibody Therapeutics is dominated by North America because of the region's strong healthcare system, intensive R&D, and high rate of chronic illness.

Antibody Therapeutics Market Size to Grow USD 364180 Million by 2029 at a CAGR of 11% | Valuates Reports

Retrieved on: 
Sunday, January 21, 2024

Antibody Based Therapeutics Market is projected to reach USD 364180 Million in 2029, increasing from USD 175410 Million in 2022, with a CAGR of 11.0% during the period of 2023 to 2029.

Key Points: 
  • Antibody Based Therapeutics Market is projected to reach USD 364180 Million in 2029, increasing from USD 175410 Million in 2022, with a CAGR of 11.0% during the period of 2023 to 2029.
  • The medical community's rising acceptance of antibody therapies is partly due to their expanding applicability, particularly in cancer and autoimmune illnesses.
  • The market for antibody therapies is expanding due to the rising incidence of chronic illnesses worldwide.
  • The Market for Antibody Therapeutics is dominated by North America because of the region's strong healthcare system, intensive R&D, and high rate of chronic illness.

Kymera Therapeutics Outlines Key 2024 Objectives and Strategy to Progress Leading Portfolio of Immunology and Oncology Programs

Retrieved on: 
Tuesday, January 9, 2024

ET

Key Points: 
  • ET
    WATERTOWN, Mass., Jan. 09, 2024 (GLOBE NEWSWIRE) -- Kymera Therapeutics, Inc. (NASDAQ: KYMR), a clinical-stage biopharmaceutical company advancing a new class of small molecule medicines using targeted protein degradation (TPD), today announced its corporate goals for 2024, including anticipated progress on its best-in-class pipeline of immunology and oncology programs.
  • Sanofi, which is collaborating with Kymera on the development of KT-474 outside of the oncology and immune-oncology fields, is conducting the Phase 2 studies.
  • KT-621 has potentially broad utility across a number of allergic diseases, including atopic dermatitis, asthma and chronic obstructive pulmonary disorder, among others.
  • Kymera is working to develop a biomarker-based patient selection strategy for subsequent development beyond Phase 1a.

BioCorRx Appoints Renowned Investment and Capital Markets Executive Louis Lucido as President

Retrieved on: 
Tuesday, January 9, 2024

Additionally, the Company announced that Brady Granier has submitted his letter of resignation as President of BioCorRx Inc. and Chief Executive Officer of BioCorRx Pharmaceuticals, a subsidiary of the Company, effective January 31, 2024.

Key Points: 
  • Additionally, the Company announced that Brady Granier has submitted his letter of resignation as President of BioCorRx Inc. and Chief Executive Officer of BioCorRx Pharmaceuticals, a subsidiary of the Company, effective January 31, 2024.
  • Mr. Granier's resignation did not arise as a result of any disagreement with the Company nor BioCorRx Pharmaceuticals.
  • Lourdes Felix, CEO, CFO, and Director of BioCorRx Inc., commented, “I am pleased to announce Louis’ appointment to Interim President of BioCorRx effective immediately and his transition to President of BioCorRx in February.
  • Louis’ breadth of experience in corporate finance and capital markets will be invaluable as we execute our growth strategy and plan for a Nasdaq listing.”
    Mr. Lucido has been a Director of BioCorRx Inc. since March 1, 2019.

CRISPR Therapeutics Highlights Strategic Priorities and 2024 Outlook

Retrieved on: 
Monday, January 8, 2024

ZUG, Switzerland and BOSTON, Jan. 08, 2024 (GLOBE NEWSWIRE) -- CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, today highlighted its strategic priorities and 2024 outlook as the Company enters its next phase of growth.

Key Points: 
  • ZUG, Switzerland and BOSTON, Jan. 08, 2024 (GLOBE NEWSWIRE) -- CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, today highlighted its strategic priorities and 2024 outlook as the Company enters its next phase of growth.
  • Exa-cel is the first therapy to emerge from a strategic partnership between CRISPR Therapeutics and Vertex Pharmaceuticals.
  • Vertex leads global development, manufacturing, regulatory and commercialization of CASGEVY with support from CRISPR Therapeutics.
  • CRISPR Therapeutics continues to focus on resource efficiency and return on invested capital as it advances multiple clinical programs across its pipeline.