ORYZON to Present at Upcoming Virtual International Conferences

• 28^th European Congress of Psychiatry, EPA 2020
  
• Alzheimer's Association International Conference, AAIC 2020
• Epigenetic Therapeutic Targets Summit 2020

MADRID, Spain and CAMBRIDGE, Mass., July 02, 2020 (GLOBE NEWSWIRE) -- Oryzon Genomics, S.A. (ISIN Code: ES0167733015, ORY), a clinical-stage biopharmaceutical company leveraging epigenetics to develop therapies in diseases with strong unmet medical need, announced today that Executive Directors of the company will present at several reputed international conferences in July, all of them to be held virtually.

Dr. Roger Bullock, Oryzon’s CMO, will attend the 28^th European Congress of Psychiatry, EPA 2020, which will be held on July 4-7. Dr. Bullock will present an e-Poster entitled “Vafidemstat reduces aggressiveness in three different psychiatric disorders. Final data from the REIMAGINE trial". For more information about this event, please visit: https://epa-congress.org/

Dr. Bullock will also attend the Alzheimer's Association International Conference, AAIC 2020, to be held on July 27-31. Dr. Bullock will deliver an oral presentation entitled "Vafidemstat in mild to moderate Alzheimer’s disease: The ETHERAL study European cohort interim analysis". For more information about this event, please visit: https://www.alz.org/aaic/overview.asp

Dr. Robert Soliva, Drug Discovery Director of Oryzon will attend the Epigenetic Therapeutic Targets Summit 2020, which will be held on July 28, where he will deliver an oral presentation entitled “Modulation of the Lysine Specific Demethylase 1 with iadademstat and vafidemstat: Cancer, Cognition and Behavior”. In the same conference, Dr. Tamara Maes, Oryzon’s CSO, will participate as panelist in the discussion panel “Toxicity and off-target effects". For more information about this event, please visit: https://epigenetic-targets.com

About Oryzon

Founded in 2000 in Barcelona, Spain, Oryzon (ISIN Code: ES0167733015) is a clinical stage biopharmaceutical company considered as the European champion in Epigenetics. Oryzon has one of the strongest portfolios in the field. Oryzon’s LSD1 program has rendered two compounds, vafidemstat and iadademstat, in clinical trials. In addition, Oryzon has ongoing programs for developing inhibitors against other epigenetic targets. Oryzon has a strong technological platform for biomarker identification and performs biomarker and target validation for a variety of malignant and neurological diseases. Oryzon has offices in Spain and the United States. For more information, visit www.oryzon.com

About Iadademstat

Iadademstat (ORY-1001) is a small oral molecule, which acts as a highly selective inhibitor of the epigenetic enzyme LSD1 and has a powerful differentiating effect in hematologic cancers (See Maes et al., Cancer Cell 2018 Mar 12; 33 (3): 495-511.e12.doi: 10.1016 / j.ccell.2018.02.002.). A first Phase I/IIa clinical trial with iadademstat in refractory and relapsed acute leukemia patients demonstrated the safety and good tolerability of the drug and preliminary signs of antileukemic activity, including a CRi. Beyond hematological cancers, the inhibition of LSD1 has been proposed as a valid therapeutic approach in some solid tumors such as small cell lung cancer (SCLC), medulloblastoma and others. Oryzon is conducting two Phase IIa clinical trials of iadademstat in combination; the first one in combination with azacitidine in elderly AML patients (ALICE study) and the second one in combination with platinum/etoposide in second line SCLC patients (CLEPSIDRA study). In both studies, preliminary clinical results have been reported.

About Vafidemstat

Vafidemstat (ORY-2001) is an oral, CNS optimized LSD1 inhibitor. The molecule acts on several levels: it reduces cognitive impairment, including memory loss and neuroinflammation, and at the same time has neuroprotective effects. In animal studies vafidemstat not only restores memory but reduces the exacerbated aggressiveness of SAMP8 mice, a model for accelerated aging and Alzheimer’s disease (AD), to normal levels and also reduces social avoidance and enhances sociability in murine models. In addition, vafidemstat exhibits fast, strong and durable efficacy in several preclinical models of multiple sclerosis (MS). Oryzon has performed a Phase IIa clinical trial in aggressiveness in patients with different psychiatric disorders (REIMAGINE) and in aggressive/agitated patients with moderate or severe AD (REIMAGINE-AD), with positive preliminary clinical results reported. Additional Phase IIa clinical trials with vafidemstat are ongoing in patients with Mild to Moderate AD (ETHERAL), where a significant reduction of the inflammatory biomarker YKL40 has been observed after 6 months of treatment, and in Relapse-Remitting and Secondary Progressive MS (SATEEN).

FORWARD-LOOKING STATEMENTS
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