Global Bone Graft Substitutes Industry

NEW YORK, Jan. 15, 2019 /PRNewswire/ -- This report analyzes the worldwide markets for Bone Graft Substitutes in US$ Million.

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The US market is additionally analyzed by the following Segments: Demineralized Bone Matrix, Bone Morphogenetic Protein, Stem Cell Based Bone Grafts, and Synthetic Bone Grafts. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World.

Annual estimates and forecasts are provided for the period 2016 through 2024. Also, a five-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs.

The report profiles 42 companies including many key and niche players such as:
- AlloSource
- Baxter International, Inc.
- DePuy Synthes Companies
- Exactech, Inc.
- SeaSpine Holdings Corporation
- LifeNet Health, Inc.

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BONE GRAFT SUBSTITUTES MCP-1
MARKET ANALYSIS, TRENDS, AND FORECASTS, JANUARY 2
CONTENTS

1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

2. INDUSTRY OVERVIEW

Bone Grafts - A Prelude
Outlook
Developing Markets Hold Lucrative Potential for Bone Graft Substitutes
Rise in Volume of Orthopedic Procedures Boosts Prospects
Table 1: Global Orthopedic Surgical Procedure Volume (2010-2020) (in million) (includes corresponding Graph/Chart)
Table 2: Global Orthopedic Market by Segment (2017): Percentage Breakdown of Value Sales for Extremities, Hips, Knees, Orthobiologics, Spine, Trauma and Others (includes corresponding Graph/Chart)
Bone Grafting - An Important Procedure for Healing Fractures
Table 3: Fractures by Age Group (2017): Percentage Share Breakdown of Number of Fractures by Age Group (includes corresponding Graph/Chart)
What Drives Physicians' Choice of Bone Grafts?
Challenges for Different Bone Grafts
Patient Safety Emerges as a Top Priority
Unmet Clinical Needs to Foster R&D Engine
Advanced Allografts Encroach the Use of Autografts in Surgical Procedures
Rise in Popularity of Synthetic Bone Graft Substitutes
Bone Morphogenetic Protein - Safety Concerns Impact Growth Prospects
Stem Cell Based Bone Grafts: Promising Growth Ahead
DBM: Strong Growth but Tough Competition
Demineralized Bone Matrix (DBM) Allografts Offered by Select Companies

3. GROWTH DRIVERS, ISSUES & TRENDS

A Review of Major Factors Affecting Growth
Increasing Incidence of Degenerative Intervertebral Disc Diseases
Table 4: % of Women Affected by Osteoporosis (includes corresponding Graph/Chart)
Rising Prevalence of Arthritis and Other Orthopedic Disorders
Growing Number of Revision Orthopedic Surgeries
Rise in Spinal Fusions in Private Healthcare
Foot and Extremity Reconstruction - Promising Market for Bone Grafts
Spine Fusion - The Largest Application Market for Bone Graft Substitutes
Dental Bone Grafting - A High Potential Market
Table 5: Dental Implants Penetration Worldwide (2015) - Number of Dental Implants Placed Per 10,000 Persons in Select Countries (includes corresponding Graph/Chart)
Adoption of Dental Implants - Breakdown by Number of Implants in Select Countries
Table 6: Dental Tissue & Bone Regeneration Materials Market (2017): Percentage Share Breakdown by Segment for Allografts, Synthetics, and Xenografts (includes corresponding Graph/Chart)
Increasing Visibility of Orthobiological Products to Spur Grafting Options
Technological Advancements Drive Bone Grafts Market
A Glance at Few Recent Innovations/Research Efforts in Bone Grafts
Sea Coral Offers Perfect Biomaterial for Bone Grafts
Indian Scientists at Synthera Develop Innovative Bone Graft Substitutes
NJIT Receives Grant to Commercialize New Bone Graft Substitute Technology
Consortium to Develop SmartBonePep® Bio-hybrid Composite Bone Graft
QMUL Researchers Develop Inductigraft Synthetic Bone Grafts
Researchers Develop Aerograft Dental Bone Graft Material for Dental Procedures
Precision Machined Allografts Gain Surgeon Preference
Disease Transmission through Bone Grafts - A Major Safety Concern
Lack of Standards in Bone Graft Substitute Market
Reimbursement Issues Continue to Haunt Bone Grafts Market
Regional Regulations & Religious Beliefs Hamper Bone Graft Substitutes Market
Synthetic Bone Grafts - Solution for Halal Bone Graft Implantation
Bone Glue - A Potential Threat to the Bone Graft Market
Alliances with Organ Procurement Organizations: A Shot in the Arm
Limited Availability of Donor Tissues
Competition Intensifies from Alternative Tissue Repair Therapies
Substitute Technologies Threaten to Replace Spinal Fusions
Bone Grafts Termed as Tissues Suffer From Inconsistent Patient Outcomes
New Ways of Fixing Broken Bones
BoneCure Sleeve - Heading Towards the Human Market
Bioactive Glass - Suitable for Weight Bearing Portion
Review of Demographic Drivers
Aging Population: A Strong Demographic Driver
Table 7: Global Aging Population in Select Regions/Countries: Population of 60+ Individuals in '000s and as a Percentage of Total Population for 2015 & 2
(includes corresponding Graph/Chart)
Rise in Global Obesity Epidemic Boosts Market Growth
Facts & Statistics on the Rising Obesity Levels: Important Opportunity Indicators
Table 8: World Obesity Prevalence (2015 & 2022): Percentage of Obese Population for Leading Ten Countries (includes corresponding Graph/Chart)

4. PRODUCT OVERVIEW

Bone Grafts: A Definition
Bone Grafts: A Peek into their Mechanism of Action
Types of Bone Grafts
Scoring of Osteoconduction, Osteoinduction, and Osteogenesis Properties of Bone Grafts by Type
Autografts
Standard Allografts
Machined Bone Allografts
Demineralized Bone Matrix
Bone Morphogenetic Proteins (BMPs)
Basic Functions of TGF-Beta
Synthetic Bone Grafts
Collagen-based Matrices
Ceramic: A Material of Choice
Hydroxyapatite: A Major Calcium Phosphate Based Ceramic
Calcium Sulfate
Polymer Based Bone Grafts
Coral: A Valuable Synthetic Graft Material
Application of Bone Grafts
Spinal Fusion
Trauma & Reconstructive Surgeries
Trauma
Reconstructive Surgeries
Joint Revision Arthroplasty
Oral, Periodontal, and Cranio-Maxillofacial
Tissue Recovery & Processing: A Review
Tissue Banks
Tissue Processing
Tissue Distribution
An Illustration of the Tissue Recovering, Processing, & Distribution Network

5. REGULATORY ENVIRONMENT

Regulatory Issues
FDA Classification of Bone Products
Human Cells, Tissues and Cellular and Tissue-Based Products (HCT/Ps)
National Organ Transplant Act (NOTA)
Good Tissue Practices
Tissue Banking Regulation
FDA Regulations on Xenograft
DBM-based Products in US
Synthetic Bone Graft Substitutes

6. COMPETITIVE LANDSCAPE

Bone Graft Products of Select Players
6.1 Focus on Select Players
AlloSource (USA)
Baxter International, Inc. (USA)
DePuy Synthes Companies (USA)
Exactech, Inc. (USA)
SeaSpine Holdings Corporation (USA)
LifeNet Health, Inc. (USA)
Medtronic plc (Ireland)
NovaBone Products LLC (USA)
NuVasive, Inc. (USA)
Orthofix International N V (Curaçao)
RTI Surgical, Inc. (USA)
Smith & Nephew Plc (UK)
Stryker Corporation (USA)
Wright Medical Group N.V. (Netherlands)
Xtant Medical Holdings, Inc. (USA)
Zimmer Biomet Holdings, Inc. (USA)
6.2 Product Innovations/Introductions
AlloSource and Stryker Unveil the ProChondrix®CR Cryopreserved Osteochondral Allograft
LifeNet Health launches AngioGraft® Aortoiliac Artery
Royal Biologics Launches MAXX™-FuseLine of Allografts
NovaBone launches NovaBone IRM and IRM MacroPOR Biologically Active Bone Graft Substitutes
Leader Biomedical Group DBM, cleaned with eCOO® Clean Technology
Antibe Therapeutics Launches PentOS OI™ Max for Dental Biologics Market
Zimmer Biomet Introduces PrimaGen Advanced Allograft
Citagenix Launches PentOS OI™ Putty Bone Graft Substitute
AlloSource® Introduces ProChondrix® Cartilage Restoration Matrix
6.3 Recent Industry Activity
Bonesupport Enters into Agreement with Collagen Matrix
DePuy Synthes Enters into Agreement with Prosidyan to Promote the FIBERGRAFT® Family of Products in the US
Medtronic Receives FDA Approval of Infuse(TM) Bone Graft in New Spine Surgery Indications
Exactech Completes Merger with TPG Capital
Molecular Matrix Receives FDA Clearance for Osteo-PTM Synthetic Bone Graft Substitute
RTI Surgical to Acquire Zyga Technology
SeaSpine Receives FDA 510(k) Clearance for OsteoBallast™ Demineralized Bone Matrix in Resorbable Mesh
BONESUPPORT™ Signs Agreement for Bio-Ceramic Bone Substitute Products in the Italian Market
Prosidyan Receives FDA 510(k) Clearance for FIBERGRAFT® BG Matrix - Bone Graft Substitute for Postero-lateral Spinal Fusion
DSM Enters into Partnership with Cerapedics to Develop and Manufacture Next Generation of Peptide Enhanced Bone Graft
Artoss Announces Availability of NanoBone Bone Graft Products through DAPA
Bonesupport™ Enters into Commercialization Agreement for the French Market
BoneSupport Extends Distribution agreement with Zimmer Biomet for Cerament TM Bone Void Filler
Kuros Biosciences Acquires Xpand Biotechnology
AllowSource Receives Patent for ProChondrix® Cartilage Restoration Matrix
MiMedx Group Takes Over Stability Biologics

7. GLOBAL MARKET PERSPECTIVE

Table 9: World Recent Past, Current and Future Analysis for Bone Graft Substitutes by Geographic Region/Country - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 10: World Historic Review for Bone Graft Substitutes by Geographic Region/ Country - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 11: World 14-Year Perspective for Bone Graft Substitutes by Geographic Region/Country - Percentage Breakdown of Revenues for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2011, 2018 & 2024 (includes corresponding Graph/Chart)

8. REGIONAL MARKET PERSPECTIVE

8.1 The United States
A.Market Analysis
US-The Largest Market for Bone Graft Substitutes
Aging Population: A Weighty Demographic Growth Factor
Table 12: North American Elderly Population by Age Group (1975-2050) (includes corresponding Graph/Chart)
Table 13: US Population Breakdown by Age Group (2017) (includes corresponding Graph/Chart)
Rising Incidence of Degenerative Intervertebral Disc Diseases
Back Pain
Arthritis
Table 14: % of Population Diagnosed with Arthritis by Age Group (includes corresponding Graph/Chart)
Osteoporosis
Table 15: Breakdown of Osteoporotic Fractures by Site in the US (includes corresponding Graph/Chart)
Rise in Revision Orthopedic Surgeries Bodes Well for Bone Graft Substitutes Market
Synthetic Bone Grafts to Drive Growth
Stem Cell Bone Grafts: A Promising Segment in BGS Market
Spinal Surgery Market: Opportunity for Bone Grafts Market
Table 16: US Spinal Fusion Surgery Market: Percentage Breakdown of Procedure Volume by Age Group (includes corresponding Graph/Chart)
Dental Bone Graft Substitutes Market: An Overview
Table 17: Dental Implants Market in the US - Incidence of Dental Implant Procedures in '000s for the Years 2016, 2020 & 2025 (includes corresponding Graph/Chart)
Orthopedic Biomaterials Market - An Overview
Orthobiologics Market - Overview
Regulatory Challenges Limit Growth in the Bone Graft Substitutes
Competitive Scenario
Table 18: US Market for Bone Graft Substitutes (2017E): Percentage Market Share Breakdown of Leading Suppliers (includes corresponding Graph/Chart)
B.Market Analytics
Table 19: US Recent Past, Current and Future Analysis for Bone Graft Substitutes by Product Segment - Demineralized Bone Matrix (DBM), Bone Morphogenetic Protein (BMP), Stem Cell Based Grafts, and Synthetic Bone Grafts Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 20: US Historic Review for Bone Graft Substitutes by Product Segment - Demineralized Bone Matrix (DBM), Bone Morphogenetic Protein (BMP), Stem Cell Based Grafts, and Synthetic Bone Grafts Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 21: US 14-Year Perspective for Bone Graft Substitutes by Product Segment - Percentage Breakdown of Revenues for Demineralized Bone Matrix (DBM), Bone Morphogenetic Protein (BMP), Stem Cell Based Grafts, and Synthetic Bone Grafts Markets for Years 2011, 2018 & 2024 (includes corresponding Graph/Chart)
8.2 Canada
Market Analysis
Table 22: Canadian Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2016 through 2
(includes corresponding Graph/Chart)
Table 23: Canadian Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
8.3 Japan
A.Market Analysis
Current and Future Analysis
Dental Bone Graft Substitutes Market
B.Market Analytics
Table 24: Japanese Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2016 through 2
(includes corresponding Graph/Chart)
Table 25: Japanese Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
8.4 Europe
A.Market Analysis
European Market for Bone Graft Substitutes: An Overview
Table 26: European Bone Graft Substitutes Market (2017): Percentage Share Breakdown of Value Sales for Synthetic, Allograft, and DBM (includes corresponding Graph/Chart)
Synthetic Bone Graft Drives the BGS Market
Bone Morphogenetic Protein (BMP) Market
Dental Biomaterials Market in Europe: An Insight
B.Market Analytics
Table 27: European Recent Past, Current and Future Analysis for Bone Graft Substitutes by Geographic Region/Country - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 28: European Historic Review for Bone Graft Substitutes by Geographic Region/Country - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 29: European 14-Year Perspective for Bone Graft Substitutes by Geographic Region/Country - Percentage Breakdown of Revenues for France, Germany, Italy, UK, Spain and Rest of Europe Markets for Years 2011, 2018 & 2
(includes corresponding Graph/Chart)
8.5 Asia-Pacific
A.Market Analysis
Current and Future Analysis
Dental Bone Graft Substitutes Market in Asia-Pacific - An Overview
Table 30: Leading Players in the Dental Bone Graft Substitutes Market in Asia-Pacific (2015E): Percentage Share Breakdown of Sales for Geistlich and Others (includes corresponding Graph/Chart)
Table 31: Over 65 Years Individuals as % of Total Population in Select Asian Countries (2015) (includes corresponding Graph/Chart)
Focus on Select Regional Markets
Australia
Table 32: Dental Bone Graft Substitutes Market in Australia (2020P): Percentage Share Breakdown of Volume Sales by Segment - Demineralized Allografts, Mineralized Allografts, Synthetic Grafts, and Xenografts (includes corresponding Graph/Chart)
China
India
Current and Future Analysis
Malaysia
South Korea
Table 33: Dental Bone Graft Substitutes Market in South Korea (2015E): Percentage Share Breakdown of Volume Sales by Material - Allograft, Synthetic Graft and Xenograft (includes corresponding Graph/Chart)
Singapore
B.Market Analytics
Table 34: Asia-Pacific Recent Past, Current and Future Analysis for Bone Graft Substitutes by Geographic Region/Country - China, India and Rest of Asia-Pacific Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 35: Asia-Pacific Historic Review for Bone Graft Substitutes by Geographic Region/Country - China, India and Rest of Asia-Pacific Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 36: Asia-Pacific 14-Year Perspective for Bone Graft Substitutes by Geographic Region/ Country - Percentage Breakdown of Revenues for China, India and Rest of Asia-Pacific Markets for Years 2011, 2018 & 2024 (includes corresponding Graph/Chart)
8.6 Latin America
A.Market Analysis
Current and Future Analysis
Dental Bone Graft Substitutes Market
Table 37: Percentage of People with Edentulous Jaws by in Brazil (2000, 2010 & 2015) (includes corresponding Graph/Chart)
Brazilian Orthopedic Devices Market
B.Market Analytics
Table 38: Latin American Recent Past, Current and Future Analysis for Bone Graft Substitutes by Geographic Region/Country - Brazil and Rest of Latin America Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 39: Latin American Historic Review for Bone Graft Substitutes by Geographic Region/ Country - Brazil and Rest of Latin America Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2011 through 2
(includes corresponding Graph/Chart)
Table 40: Latin American 14-Year Perspective for Bone Graft Substitutes by Geographic Region/Country - Percentage Breakdown of Revenues for Brazil and Rest of Latin America Markets for Years 2011, 2018 & 2024 (includes corresponding Graph/Chart)
8.7 Rest of World
A.Market Analysis
Current and Future Analysis
B.Market Analytics
Table 41: Rest of World Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 42: Rest of World Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)

9. COMPANY PROFILES

Total Companies Profiled: 57 (including Divisions/Subsidiaries - 60) The United States (38) Canada (1) Europe (17) - France (2) - Germany (2) - The United Kingdom (4) - Rest of Europe (9) Asia-Pacific (Excluding Japan) (3) Africa (1)
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