Toyoda Gosei Develops Urethane Microfoam Film to Cultivate Cells for Drug Discovery

Error message

Notice: Undefined property: stdClass::$ds_changed in eval() (line 16 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ss_search_api_url in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$tm_title in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ds_changed in eval() (line 16 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ss_search_api_url in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$tm_title in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ds_changed in eval() (line 16 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ss_search_api_url in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$tm_title in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ds_changed in eval() (line 16 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ss_search_api_url in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$tm_title in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ds_changed in eval() (line 16 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ss_search_api_url in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$tm_title in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ds_changed in eval() (line 16 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ss_search_api_url in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$tm_title in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ds_changed in eval() (line 16 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ss_search_api_url in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$tm_title in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ds_changed in eval() (line 16 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$ss_search_api_url in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).
Notice: Undefined property: stdClass::$tm_title in eval() (line 20 of /var/www/7/modules/php/php.module(80) : eval()'d code).

Toyoda Gosei Co., Ltd. (TOKYO:7282) has developed a urethane microfoam film for cell culture, using the knowledge of urethane materials it has gained in the development and production of steering wheels.

Metadata

Provider:

Business Wire, Inc.

Retrieved on:

Wednesday, November 4, 2020

Information

Tags:

Science, Biotechnology, Research, Pharmaceutical, Other Manufacturing, Health, Manufacturing, Other Health, Toyoda, Animal testing, Science, Applied ethics

Geotags:

Japan

⚠generated by AI ↴

Summary

Key Points:

Toyoda Gosei Co., Ltd. (TOKYO:7282) has developed a urethane microfoam film for cell culture, using the knowledge of urethane materials it has gained in the development and production of steering wheels.
This film allows cells to be cultivated with a structure close to that of certain living tissues, and is promising as an alternative to animal experiments and for other uses in new drug development.
Toyoda Gosei will continue to leverage its core technologies to contribute to medical advances.
Toyoda Gosei will announce this technology at the 33rd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments held online on 12 and 13 November.

Toyoda Gosei Co., Ltd. (TOKYO:7282) has developed a urethane microfoam film for cell culture, using the knowledge of urethane materials it has gained in the development and production of steering wheels. This film allows cells to be cultivated with a structure close to that of certain living tissues, and is promising as an alternative to animal experiments and for other uses in new drug development. The company is currently conducting pharmacokinetic studies* for early practical application.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20201103005814/en/

Image of cell culture (Graphic: Business Wire)

A key feature of the urethane film is that two kinds of cells can be cultivated in a two-layered tissue structure close to that of living tissues such as blood vessels and the intestinal epithelium. This is achieved with the film’s ability not only to separate the two kinds of cells on opposite sides of the film and keep them from mixing with each other, but also to allow the two kinds of cells to contact each other through countless U-shaped through pores in the film. The size of these pores can be controlled at the micrometer level.

In new drug development, this two-cell layer tissue will enable detailed examination of the movement of a drug in individual cell layers similar to those in the living body. This will lead to alternatives to some animal experiments, which are used to assess drug efficacy and safety, and help to narrow the list of candidate drugs in the early phase. In this way it will contribute to shorter development periods and lower development costs.

Toyoda Gosei will continue to leverage its core technologies to contribute to medical advances.

Toyoda Gosei will announce this technology at the 33rd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments held online on 12 and 13 November.

Name		The 33^rd Annual Meeting of the Japanese Society for Alternatives to Animal Experiments
Dates		12 and 13 November 2020 (All day)
Venue		Website (URL https://jsaae33.secand.net/english.html)
Theme		Double layered co-culture for direct interaction between Caco-2 and human vein endothelial cells by using the membrane with U-shaped through pore

*In vitro studies to assess a drug’s benefits and side effects by investigating the drug’s activities (cell absorption, distribution, metabolism and excretion).

View source version on businesswire.com: https://www.businesswire.com/news/home/20201103005814/en/