Chromosome

• PROVIDENCE, R.I., March 7, 2024 /PRNewswire/ -- Next generation genomic tools company, Nabsys®, has executed a nonexclusive agreement with Canadian distributor, DMark Biosciences ("DMark"), for sales of its OhmX™ platform.
• OhmX is Nabsys' first commercially available product and was released in October 2023.
• DMark will be responsible for distributing both the Nabsys OhmX™ Analyzer and consumables into both public and private research core labs and institutions in the Canadian market.
• "With growing demand for the OhmX platform in the US, this distribution agreement marks an important step towards establishing a strong global distribution network," Nabsys' Chief Commercial Officer, Justin Bingham, remarked.

• This has made it difficult for scientists to understand early human development.
• By offering new tools to explore the enigmatic earliest stages of human development, synthetic embryology can help researchers overcome the challenges of using real human embryos.
• With these new models, researchers can also better understand conditions that affect human reproduction and development as well as maternal-fetal health, potentially leading to new therapies.

Making human embryos from stem cells

• This triggers the egg to rapidly divide into embryonic cells that soon form an inner cell mass that eventually develops into the fetus and a outer layer of cells that will give rise to the placenta.
• Synthetic embryology artificially recreates these developmental stages using human pluripotent stem cells derived from human embryos or induced from adult human cells.
• Like early embryonic cells, these cells have the ability to develop into any type of cell in the human body.

• Researchers created the first human embryo model from embryonic stem cells in 2014.
• This pioneering model, also called a gastruloid, captured key aspects of early human development and showed that scientists can drive pluripotent stem cells to form patterned layers echoing the three germ layers and the outer layers of the embryo.

Advancements in human embryo models

• Over the years, various models have been able to replicate different facets of human embryogenesis, such as amniotic sac development, germ layer formation and body plan organization.
• However, none of these models fully captures the entire process of a single cell type developing into the complete structure of a whole embryo.
• Blastoids form in a similar way to human embryos, starting from just a few cells that proliferate and organize themselves.
• Recently, researchers have successfully created more complex models in the lab that mimic what happens after embryos attach to the womb.

Choosing the right models

• This goal underscores the importance of carefully choosing the model best suited to the specific research objectives at hand.
• Creating embryo models from a patient’s own cells could also allow researchers to study the genetics of development and aid in personalizing treatments.
• The International Society for Stem Cell Research strictly prohibits transferring these embryo models into the uterus of a human or an animal.
• Although these models mimic certain features of early developmental stages, they cannot and will not develop into the equivalent of a human baby after birth.

Min (Mia) Yang receives funding from University of Washington

• “Receiving this grant is deeply gratifying,” says Dr. Joaquín Espinosa, Professor in Pharmacology and Executive Director of the Crnic Institute.
• “Everyone at the Crnic Institute, GLOBAL and all our Affiliates have worked so hard in the last ten years to take our remarkable findings from the Petri dish and parlay that into benefit for people with Down syndrome.
• Key outstanding questions specific to individuals with Down syndrome will be addressed:
  What are the impacts of interferon hyperactivity during early childhood?
• From over 165 letters of intent and ultimately 56 full proposals, 9 research projects were funded.

• The "Molecular Diagnostics in Oncology, Genetic/Inherited Diseases, and NIPT, 2023-2028" report has been added to ResearchAndMarkets.com's offering.
• In addition, the fields of rare inherited/ genetic diseases and NIPT have become areas of new breakthroughs in healthcare.
• These and other technologies and applications in oncology, rare inherited/ genetic disease, and NIPT molecular diagnostic testing are covered in the report.
• The report contains detailed market data on the following IVD segments for their use in molecular testing:
  Molecular Diagnostics in Oncology Market by Segment, 2023-2028