Skeletal muscle

New Study Describes First, Functional Human Model to Investigate Opiate Overdose and Recovery

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Giovedì, Settembre 7, 2023
University, Biotechnology, Education, Technology, Health, Pharmaceutical, Other Science, Other Technology, Research, Nanotechnology, Science, Molecular biology, Central Florida, Spanish National Center for Biotechnology, Heart, Neuron, Human, Cell biology, Therapy, Opioid, Naloxone, UCF, Systems biology, Public, Initiative, NCATS, Fentanyl, Toxicity, National Center for Advancing Translational Sciences, Bangladesh Technical Education Board, Skeletal muscle, Bio-MEMS, Chemistry, Development, Student, Patient, Electrophysiology, Engineering, Kidney, Drug discovery, Faculty, Drug, Liver, NSTC, HSL, Death, NIH, Medical imaging, Pharmaceutical industry

The study, "Human IPSC-Derived PreBötC-like Neurons and Development of an Opiate Overdose and Recovery Model" ( doi.org/10.1002/adbi.202300276 ) was published in Advanced Biology on September 7, 2023.

Key Points: 
  • The study, "Human IPSC-Derived PreBötC-like Neurons and Development of an Opiate Overdose and Recovery Model" ( doi.org/10.1002/adbi.202300276 ) was published in Advanced Biology on September 7, 2023.
  • The paper describes the development of human preBötC neurons from induced pluripotent cells (iPSCs) and the establishment of a human model that mimics opioid overdose with four opioids and the recovery of neuronal activity with naloxone treatment.
  • The dose-dependent inhibition of these neurons’ activity was demonstrated with four opioids, including Fentanyl - the primary culprit of overdose deaths.
  • “This research provides an accurate way to model overdose in the lab, using human brain cells programmed to respond to many different opioids,” said Rebecca Baker.

Imagine This Women's Film Festival Returns September 22 - October 1, 2023, To New York City With An Exciting Lineup Of Screening, Panels, And Events Featuring Academy Award-Winning Director Carlos López Estrada And Emmy Award-Winning Filmmaker Linda Mendo

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Mercoledì, Settembre 6, 2023
Cloud, Linda, Le Pain Quotidien, External, The Heights, Kate Dickie, Woman, Drama, Motion, Gold, Academy Awards, Love, Multicultural education, Motion Picture Association, Driving, To the Death, Parm, Film festival, Film industry, Entertainment, Skeletal muscle, Death

NEW YORK, Sept. 6, 2023 /PRNewswire/ -- The 8th Annual Imagine This Women's Film Festival is back with an exhilarating lineup that promises three days of captivating panels, screenings, and exclusive events. This year's festival features a compelling selection of 112 films, including 12 highly anticipated world premieres, 27 regional premieres, and an impressive lineup of 13 North American premieres. Additionally, 15 films are set to premiere exclusively in the vibrant city of New York, further enhancing the festival's allure.

Key Points: 
  • Additionally, 15 films are set to premiere exclusively in the vibrant city of New York, further enhancing the festival's allure.
  • The festival kicks off on September 22 with the North American premiere of Heights and Depths, an emotionally charged film exploring themes of loss.
  • Opening Night Party: Join us on September 22 for the grand Opening Night Party at Cloud One Hotel, located at 133 Greenwich St, New York, NY 10006.
  • It's a night of celebration, mingling with filmmakers, and setting the tone for an unforgettable festival.

Elevate Your Fitness Journey with MitoSculpt by Nutrishop

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Mercoledì, Settembre 6, 2023
Exercise, Heart, Human, Panax notoginseng, History, Skeletal muscle, Lipid metabolism, Health, McLendon, Safety, Dietary supplement, Coleus

HENDERSON, Nev., Sept. 6, 2023 /PRNewswire/ -- Nutrishop® is proud to announce the launch of MitoSculpt™ by Illicit Labs®. This revolutionary metabolic formula was meticulously crafted with cutting-edge ingredients to support your fitness journey. MitoSculpt is stimulant-free, which makes it a great choice for those looking to manage their weight without the effects of high stimulants. This innovative product is now available exclusively at Nutrishop locations nationwide and online at NutrishopUSA.com.

Key Points: 
  • This revolutionary metabolic formula was meticulously crafted with cutting-edge ingredients to support your fitness journey.
  • "For those who prefer stimulants, MitoSculpt stacks really well with stimulant-based thermogenic supplements for an even greater effect when it comes to supporting your fitness journey," said McLendon.
  • As always, Nutrishop recommends speaking with your health care provider before embarking on any fitness journey to ensure health and safety first.
  • MitoSculpt is now available exclusively at Nutrishop locations across the United States and at NutrishopUSA.com .

Rugby World Cup: why hamstring injuries are so prevalent in the sport

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Martedì, Settembre 5, 2023
Exercise, Skeletal muscle, Hamstring, Concussion, Human, Delayed onset muscle soreness, Fatigue, Eye, World, Leg, Research, History, Movement, Muscle weakness, Athlete, Team, MRI, Running, Thigh, Risk, Rugby World Cup, Anatomy, Sport, Torso, Knee, Body size and species richness, Injury, Sports equipment, Dietary supplement, Nordic

Soft tissue injuries, particularly hamstring injuries, have already ruled several players out of the World Cup, raising questions about why such incidents are so common.

Key Points: 
  • Soft tissue injuries, particularly hamstring injuries, have already ruled several players out of the World Cup, raising questions about why such incidents are so common.
  • And hamstring strains are the most common, contributing to 15% of all injuries in rugby union.
  • In the previous Rugby World Cup in 2019, hamstring injuries were the second most common match injury after concussion and accounted for nearly 50% of all missed training or playing days.

Anatomy of the hamstring muscles

    • Pushing these muscles beyond their limits through stretching or overloading can lead to painful injuries, with the muscles potentially tearing.
    • Muscles often work in pairs and some experts believe that an imbalance between the quadriceps muscles at the front of the thigh and the hamstring muscles at the back could also contribute to the problem.

What we found

    • We discovered that the hamstring muscles of rugby players showed greater stiffness compared to the other group.
    • So, as expected, our MRI analysis showed that the quadriceps muscles at the front of the thigh were significantly larger in rugby players relative to body size.
    • But our research points to an interesting discrepancy – rugby players displayed an imbalance in size between their quadriceps and hamstring muscles.

Is there a solution?

    • For instance, it’s important to keep an eye on older athletes and those with previous hamstring injuries, and manage fatigue appropriately.
    • Encouraging athletes to have a comprehensive warm-up routine is also crucial.
    • When muscles warm, they become more elastic, which might help them handle strain better and potentially prevent tearing.
    • This exercise has been suggested to cut the rate of hamstring injuries in half among athletes in team sports.

Zepp Health Launches Amazfit Balance with AI-empowered Features for the Ultimate in Balanced Living

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Venerdì, Settembre 1, 2023
Knowledge, Sleep, Life, Behavioral sleep medicine, Mental, Hospital, European, Relaxation, NYSE, Research, USD, American Board of Commissioners for Foreign Missions, Zepp, Work, PPG, BMI, Body composition, Balance, LLM, Knowledge base, GTS, Water, Rest, Basal metabolic rate, Partnership, Wrist, Skeletal muscle, Mastercard, United Kingdom, Meditation, Ecosystem, Health, Mobile phone, Medical device, Nursing, Amazfit, Curve

MILPITAS, Calif., Sept. 1, 2023 /PRNewswire/ -- Zepp Health Corporation ("Zepp Health") (NYSE: ZEPP), a global leader in smart wearables and health technology, has today announced the launch of the Amazfit Balance. Created to help people achieve the ultimate balance of life, work, and wellness, the Amazfit Balance takes the baton from the brand's Amazfit GTR and GTS family of smartwatches, building on the cutting-edge technology and features that made those models resonate so powerfully with a global community of users, and empowered by Zepp Health's evolving AI ecosystem to become the new leader of Amazfit's Lifestyle Series. 

Key Points: 
  • Convenient Contactless Payments enabled on Amazfit Balance Smartwatches with Zepp Pay, powered by Mastercard
    MILPITAS, Calif., Sept. 1, 2023 /PRNewswire/ -- Zepp Health Corporation ("Zepp Health") (NYSE: ZEPP), a global leader in smart wearables and health technology, has today announced the launch of the Amazfit Balance.
  • Zepp Pay contactless payment, facilitated by Amazfit partnerships with several Mastercard issuing banks, such as Curve in 31 countries and regions.
  • Amazfit Balance users in the US and Europe will receive a complimentary three-month trial of the Zepp Aura Premium service upon purchase.
  • The Amazfit Balance is now available via the official Amazfit website, with prices starting from $229.99 USD / €249.90.

Zepp Health Launches Amazfit Balance with AI-empowered Features for the Ultimate in Balanced Living

Retrieved on: 
Venerdì, Settembre 1, 2023
Knowledge, Sleep, Life, Behavioral sleep medicine, Mental, Hospital, European, Relaxation, NYSE, Research, USD, American Board of Commissioners for Foreign Missions, Zepp, Work, PPG, BMI, Body composition, Balance, LLM, Knowledge base, GTS, Water, Rest, Basal metabolic rate, Partnership, Wrist, Skeletal muscle, Mastercard, United Kingdom, Meditation, Ecosystem, Health, Mobile phone, Medical device, Nursing, Amazfit, Curve

MILPITAS, Calif., Sept. 1, 2023 /PRNewswire/ -- Zepp Health Corporation ("Zepp Health") (NYSE: ZEPP), a global leader in smart wearables and health technology, has today announced the launch of the Amazfit Balance. Created to help people achieve the ultimate balance of life, work, and wellness, the Amazfit Balance takes the baton from the brand's Amazfit GTR and GTS family of smartwatches, building on the cutting-edge technology and features that made those models resonate so powerfully with a global community of users, and empowered by Zepp Health's evolving AI ecosystem to become the new leader of Amazfit's Lifestyle Series. 

Key Points: 
  • Convenient Contactless Payments enabled on Amazfit Balance Smartwatches with Zepp Pay, powered by Mastercard
    MILPITAS, Calif., Sept. 1, 2023 /PRNewswire/ -- Zepp Health Corporation ("Zepp Health") (NYSE: ZEPP), a global leader in smart wearables and health technology, has today announced the launch of the Amazfit Balance.
  • Zepp Pay contactless payment, facilitated by Amazfit partnerships with several Mastercard issuing banks, such as Curve in 31 countries and regions.
  • Amazfit Balance users in the US and Europe will receive a complimentary three-month trial of the Zepp Aura Premium service upon purchase.
  • The Amazfit Balance is now available via the official Amazfit website, with prices starting from $229.99 USD / €249.90.

Zepp Health Launches Amazfit Balance with AI-empowered Features for the Ultimate in Balanced Living

Retrieved on: 
Venerdì, Settembre 1, 2023
Knowledge, Sleep, Life, Behavioral sleep medicine, Mental, Hospital, European, Relaxation, NYSE, Research, USD, American Board of Commissioners for Foreign Missions, Zepp, Work, PPG, BMI, Body composition, Balance, LLM, Knowledge base, GTS, Water, Rest, Basal metabolic rate, Partnership, Wrist, Skeletal muscle, Mastercard, United Kingdom, Meditation, Ecosystem, Health, Mobile phone, Medical device, Nursing, Amazfit, Curve

MILPITAS, Calif., Sept. 1, 2023 /PRNewswire/ -- Zepp Health Corporation ("Zepp Health") (NYSE: ZEPP), a global leader in smart wearables and health technology, has today announced the launch of the Amazfit Balance. Created to help people achieve the ultimate balance of life, work, and wellness, the Amazfit Balance takes the baton from the brand's Amazfit GTR and GTS family of smartwatches, building on the cutting-edge technology and features that made those models resonate so powerfully with a global community of users, and empowered by Zepp Health's evolving AI ecosystem to become the new leader of Amazfit's Lifestyle Series. 

Key Points: 
  • Convenient Contactless Payments enabled on Amazfit Balance Smartwatches with Zepp Pay, powered by Mastercard
    MILPITAS, Calif., Sept. 1, 2023 /PRNewswire/ -- Zepp Health Corporation ("Zepp Health") (NYSE: ZEPP), a global leader in smart wearables and health technology, has today announced the launch of the Amazfit Balance.
  • Zepp Pay contactless payment, facilitated by Amazfit partnerships with several Mastercard issuing banks, such as Curve in 31 countries and regions.
  • Amazfit Balance users in the US and Europe will receive a complimentary three-month trial of the Zepp Aura Premium service upon purchase.
  • The Amazfit Balance is now available via the official Amazfit website, with prices starting from $229.99 USD / €249.90.

Keros Therapeutics Reports Recent Business Highlights and Second Quarter 2023 Financial Results

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Lunedì, Agosto 7, 2023
Ruxolitinib, Therapy, PAH, Cohort, Research, Part, Disorder, Skeletal muscle, Protein, DMD, Patient, Investment, Syndrome, Biology, Orthostatic hypertension, Regulation of food and dietary supplements by the U.S. Food and Drug Administration, Food, Safety, KROS, Pharmaceutical industry

Keros expects to announce dose escalation data from and initiate Part 2 of this trial in the second half of 2023.

Key Points: 
  • Keros expects to announce dose escalation data from and initiate Part 2 of this trial in the second half of 2023.
  • Keros reported a net loss of $37.5 million in the second quarter of 2023 as compared to a net loss of $27.3 million in the second quarter of 2022.
  • Research and development expenses were $32.5 million for the second quarter of 2023 as compared to $23.3 million for the same period in 2022.
  • General and administrative expenses were $8.8 million for the second quarter of 2023 as compared to $7.4 million for the same period in 2022.

Precision BioSciences Reports Second Quarter 2023 Financial Results and Provides Business Update

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Venerdì, Agosto 4, 2023
Research, FDA, Clinical Trials, Biotechnology, Other Health, Health, Pharmaceutical, Other Science, Science, Serum, HBsAg, Congress, Development, Patient, Risk, Cell, Eli Lilly and Company, CccDNA, Infant, Hepatitis B virus, Hepatitis, Heart, Cash, University, Duchenne muscular dystrophy, Gene, Gene editing, Diaphragm, DSM-IV codes, Precision, Liver cancer, Conditional sentence, European Association for the Study of the Liver, Death, Cirrhosis, IND, Genome, Precision BioSciences, DNA, AAV, Messenger, Hepatocyte, CAR, Administration, Blood, Therapy, HBV, Hemoglobinopathy, EASL, Central nervous system, Molecular Partners, CTA, Inflammation, Skeletal muscle, State Administrative Expenses, DMD, Novartis, OTC, Sickle cell disease, NHP, Regulation of tobacco by the U.S. Food and Drug Administration, Society, Food, Pharmaceutical industry, Vaccine, Prevail, Liver

Precision BioSciences, Inc. (Nasdaq: DTIL), a clinical stage gene editing company developing ARCUS®-based in vivo gene editing and ex vivo allogeneic CAR T therapies, today announced financial results for the second quarter ended June 30, 2023 and provided a business update.

Key Points: 
  • Precision BioSciences, Inc. (Nasdaq: DTIL), a clinical stage gene editing company developing ARCUS®-based in vivo gene editing and ex vivo allogeneic CAR T therapies, today announced financial results for the second quarter ended June 30, 2023 and provided a business update.
  • “The first half of 2023 has been a busy time at Precision.
  • Cash and Cash Equivalents: As of June 30, 2023, Precision had approximately $137.8 million in cash and cash equivalents.
  • Weighted average shares of common stock outstanding were approximately 114.1 million for the quarter ended June 30, 2023, as compared to approximately 68.0 million for the quarter ended June 30, 2022.

Can't afford a gym membership or fitness class? 3 things to include in a DIY exercise program

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Martedì, Luglio 25, 2023
Exercise, Heart, Disability, Oxygen, Facial muscles, Cardiovascular disease, DIY, Next, Running, Motion, Man, High-intensity interval training, Swimming, Walking, Skeletal muscle, Menopause, Jogging, Heart rate, Death, News, HIIT, Dietary supplement, Poultry farming, Security (finance), Tutoring, Sports equipment, Conveyor system, Nursing

With the rising cost of living, gyms memberships and fitness classes are becoming increasingly unaffordable. But the good news is you can make just as much progress at home. Cardiovascular endurance, muscle strength and flexibility are the most important components of fitness. And each can be trained with little or no equipment. Let’s look at why – and how – to fit them into your DIY exercise program. 1. Cardiovascular endurance Cardiovascular endurance exercise (or “cardio”) forces the heart and lungs to increase the supply of oxygen to the working muscles.

Key Points: 


With the rising cost of living, gyms memberships and fitness classes are becoming increasingly unaffordable. But the good news is you can make just as much progress at home. Cardiovascular endurance, muscle strength and flexibility are the most important components of fitness. And each can be trained with little or no equipment. Let’s look at why – and how – to fit them into your DIY exercise program.

1. Cardiovascular endurance

    • Cardiovascular endurance exercise (or “cardio”) forces the heart and lungs to increase the supply of oxygen to the working muscles.
    • Heart disease is a leading cause of death and cardiovascular endurance exercise helps keep the heart healthy.
    • While high-intensity interval training can be more time efficient, low-intensity steady-state training might be more enjoyable and easier to sustain long-term.
    • No matter what you choose, aim for a minimum of 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity cardiovascular exercise each week.
    • Conversely, short phrases (initially) or single words (towards the end) should be all that’s manageable during high-intensity exercise.

2. Muscle strength


    Next is muscle strength, which we train through resistance exercise. This is important for bone health, balance and metabolic health, especially as we age and our muscle mass and strength declines. Aim for two days per week of whole-body resistance exercise performed at a moderate or greater intensity. Try to build two weekly sessions that target the major muscle groups. This could include:
    • As you progress, continue to challenge your muscles by adding an extra set to each exercise, or including dumbbells, changing body position or wearing a backpack with weights.
    • However, if you have any underlying health conditions, disabilities, or are unsure how best to do this, see an exercise physiologist or physiotherapist.

3. Flexibility

    • Improved flexibility can increase your range of motion and improve your ability to manage daily life.
    • While we don’t know the best means of increasing flexibility, the most basic and readily accessible is static stretching.

How to stick with it?

    • After all, it’s about creating an ongoing commitment to exercise that will deliver long-term health benefits.
    • Read more:
      New study: much of what we're told about gym exercises and resistance training is from studies of males, by men