Bone fracture

Chrysalis Receives FDA Approval to Initiate Clinical Trials with Chrysalin™ (TP508)

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Martedì, Settembre 26, 2023

Chrysalis BioTherapeutics, Inc. announced today that the US Food and Drug Administration (FDA) has given the company permission to initiate human clinical trials aimed at treating acute lung failure.

Key Points: 
  • Chrysalis BioTherapeutics, Inc. announced today that the US Food and Drug Administration (FDA) has given the company permission to initiate human clinical trials aimed at treating acute lung failure.
  • Other animal studies show potential TP508 benefit in treating acute lung injury, chronic smoke inhalation, and mitigating radiation effects on brain and other tissues.
  • “TP508 is a natural regenerative peptide that accelerates tissue repair and revascularization while modulating the inflammatory response.
  • Chrysalis is using UTMB, Houston-area, and national advisors to advance TP508 for treating pulmonary indications.

Study Published in Nature Reveals Discovery of Unique Vertebral Stem Cells with Potential to Revolutionize Patient Care

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Giovedì, Settembre 21, 2023

NEW YORK, Sept. 21, 2023 /PRNewswire/ -- In a groundbreaking study published in Nature, a collaborative team of researchers from Hospital for Special Surgery (HSS) and Weill Cornell Medicine have discovered a new stem cell uniquely present in the spine. Vertebral stem cells, distinct from other stem cells in the body, hold the key to understanding a range of conditions affecting the spine – including its higher incidence of cancerous tumor metastases, particularly from breast, prostate, and lung cancers. 

Key Points: 
  • Vertebral stem cells, distinct from other stem cells in the body, hold the key to understanding a range of conditions affecting the spine – including its higher incidence of cancerous tumor metastases, particularly from breast, prostate, and lung cancers.
  • For a long time, physicians believed all bones formed in the same way – through a universal process of ossification.
  • Specifically, the investigators identified a stem cell that is responsible for bone formation in the vertebrae.
  • However, our discovery of this vertebral stem cell provides a likely explanation of why some cancers most often spread to the spine," stated Dr. Greenblatt.

Entera Bio to Present Two Abstracts on its First-in-Class, Once Daily Oral hPTH(1-34) Peptide Tablets (EB613) for the Treatment of Post-Menopausal Women at High Risk of Fracture at the American Society for Bone and Mineral Research (ASBMR) Annual Meeting

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Mercoledì, Agosto 16, 2023

EB613 [hPTH(1-34) tablets] is being developed as the first once-daily oral anabolic (bone forming) mini tablet therapy for post-menopausal women with high risk osteoporosis.

Key Points: 
  • EB613 [hPTH(1-34) tablets] is being developed as the first once-daily oral anabolic (bone forming) mini tablet therapy for post-menopausal women with high risk osteoporosis.
  • Due to a lower peak bone density as compared to men and decreases in estradiol after menopause, women are affected in greater numbers.
  • Post menopausal osteoporosis afflicts more women globally than cancer and cardiovascular disease and is a serious health concern.
  • As potentially, the first once daily hPTH(1-34) peptide tablet therapy, our EB613 program is dedicated to address the vast treatment gap in current osteoporosis care,” said Miranda Toledano, Chief Executive Officer at Entera.

Merck Manuals Details What Patients Need to Know About Osteoporosis

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Martedì, Agosto 15, 2023

RAHWAY, N.J., Aug. 15, 2023 /PRNewswire/ -- As we get older, our bone density and bone strength diminish. In some people, that decrease can lead to osteoporosis -- a condition in which a decrease in the density of bones weakens the bones, making breaks (fractures) more likely. In a new editorial from MerckManuals.com, Marcy B. Bolster, MD, Harvard Medical School, shares five things patients should know about osteoporosis as they get older.

Key Points: 
  • Bolster, MD, Harvard Medical School, shares five things patients should know about osteoporosis as they get older.
  • During menopause, a woman's estrogen levels decrease, which contributes to a drop in bone density, Bolster explains.
  • One of the most significant osteoporosis risk factors, Bolster says, is having a parent who has experienced a hip fracture.
  • The Bone Health and Osteoporosis Foundation recommends screenings for all females aged 65 and older and all men aged 70 and older.

Safe Orthopaedics announces the publication of a biomechanical study on Sycamore

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Martedì, Agosto 8, 2023

Éragny-sur-Oise, Fleurieux sur l’Arbresle, France, le 07 août 2023 à 17h30 CET – Safe (FR001400F1V2 – ALSAF), french group specialized in the design, manufacturing and distribution of ready-to-use medical devices for Spine surgeries, especially safe for vertebral fracture treated in emergency, announces the publication of a biomechanical study of Sycamore and over 160 patients treated with Sycamore.

Key Points: 
  • Éragny-sur-Oise, Fleurieux sur l’Arbresle, France, le 07 août 2023 à 17h30 CET – Safe (FR001400F1V2 – ALSAF), french group specialized in the design, manufacturing and distribution of ready-to-use medical devices for Spine surgeries, especially safe for vertebral fracture treated in emergency, announces the publication of a biomechanical study of Sycamore and over 160 patients treated with Sycamore.
  • Leaded by Professor Jean-Charles Le Huec, the study compares the biomechanical behavior of vertebrae treated by “Dowelplasty”, a new surgical technique using a pedicle anchored device Sycamore (commercial name by Safe Orthopedics) with a traditional kyphoplasty system.
  • The study is published in the Journal of Experimental Orthopedics.
  • In comparison with the Kyphoplasty, Sycamore shows a significant increase of the compression strength (373 N ; IC à 95% ; – 331 N versus – 1076 N for Sycamore).

Dr. Andres Betts Joins Pain Medicine Associates - Mission Viejo, California

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Martedì, Luglio 18, 2023

MISSION VIEJO, Calif., July 18, 2023 /PRNewswire-PRWeb/ -- Pain Medicine Associates (PMA) is pleased to announce that interventional pain management specialist Andres Betts, M.D., has joined the company's Mission Viejo, California pain management practice. He began seeing patients on July 3rd at the office, located at 26137 La Paz Rd, Suite 140, Mission Viejo, CA 92691.

Key Points: 
  • MISSION VIEJO, Calif., July 18, 2023 /PRNewswire-PRWeb/ -- Pain Medicine Associates (PMA) is pleased to announce that interventional pain management specialist Andres Betts, M.D., has joined the company's Mission Viejo, California pain management practice.
  • He began seeing patients on July 3rd at the office, located at 26137 La Paz Rd, Suite 140, Mission Viejo, CA 92691.
  • Dr. Betts is an innovative, board-certified, fellowship trained interventional pain management physician that specializes in the diagnosis and treatment of pain disorders.
  • He founded the Pain Clinic in Bellingham, Washington and Pain MD Medical Associates in San Clemente, California.

CurvaFix Closes $39 Million Series C Financing Round Led by MVM Partners and Announces CEO Transition

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Venerdì, Luglio 14, 2023

CurvaFix, Inc ., a developer of medical devices to repair fractures in curved bones, today announced the close of a $39 million equity financing led by MVM Partners with participation from Sectoral Asset Management and other existing investors.

Key Points: 
  • CurvaFix, Inc ., a developer of medical devices to repair fractures in curved bones, today announced the close of a $39 million equity financing led by MVM Partners with participation from Sectoral Asset Management and other existing investors.
  • The company also announced that Mark Foster has been named CEO, succeeding founder and current CEO Steve Dimmer, who will transition into a strategic advisory role.
  • “CurvaFix's ability to benefit patients, physicians, and health systems, while simultaneously addressing the undertreated FFP segment makes CurvaFix a rare asset in the crowded world of orthopedics,” said Eric Fritz, MVM Partner.
  • Before joining CurvaFix, Foster was president and CEO of Trice Medical, a leader in the field of minimally invasive orthopedic procedures.

Period shame stops countless girls from continuing sport. The Women’s World Cup can help break this stigma

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Mercoledì, Luglio 12, 2023

New Zealand has also swapped out its traditional white shorts for teal blue to help combat period anxiety.

Key Points: 
  • New Zealand has also swapped out its traditional white shorts for teal blue to help combat period anxiety.
  • The shame and taboo associated with periods stops many young girls from continuing sport, and misinformation about menstruation affects the performance and health of countless elite athletes.
  • The 2023 FIFA Women’s World Cup is an opportunity to dispel period myths and put a focus on the specific needs of athletes who menstruate.

Women athletes aren’t small men

    • This research doesn’t consider the physical and psychological changes that women athletes may experience at each phase of the menstrual cycle, nor how that may affect peak performance.
    • Research into how the menstrual cycle affects the performance of women athletes is growing.

No longer a mark of honour

    • Overly intense training can cause some athletes to stop having periods.
    • This has often been considered normal by coaches and a mark of honour among athletes themselves.
    • Symptoms include periods stopping or becoming irregular, reduced performance, mood changes, and recurrent illnesses and injuries including stress fractures.

Change is happening, albeit slowly

    • For example, the Australian Institute of Sport launched an initiative in late 2019 to “improve female athlete specific knowledge and systems of support”.
    • Many women athletes themselves have started to speak up about the taboo associated with menstruation and are lobbying for change.
    • She’s now using her profile to raise awareness of women’s health issues and to try and reduce the taboo around periods.

Girls’ barriers to sport

    • Puberty, and the start of periods, is a time when girls’ participation in grassroots sport falls off sharply.
    • A UK survey of more than 4,000 teenagers published last year found there are complex barriers and deep-rooted negative attitudes affecting girls’ enjoyment of sport, including period shame and body image issues.
    • Various state governments are investing in grassroots sport facilities that better attend to the needs of women.


    These can help girls and women be empowered to manage their periods in ways that will enable them to continue their participation and not feel ashamed or embarrassed. With the world cup media spotlight, we have an unprecedented opportunity to break menstrual shame, silence and taboo.

Medimaps Group Deep-tech TBS Software Endorsed by International Experts Working Group To Inform Osteoporosis Management Decisions for The Benefit of The Patient

Retrieved on: 
Mercoledì, Luglio 5, 2023

The peer-reviewed article provides endorsed guidance to clinicians looking to enhance the assessment and management of osteoporosis with Medimaps Group TBS iNsight™ software for patient benefit.

Key Points: 
  • The peer-reviewed article provides endorsed guidance to clinicians looking to enhance the assessment and management of osteoporosis with Medimaps Group TBS iNsight™ software for patient benefit.
  • Worldwide, osteoporosis causes more than 8.9 million fractures every year, resulting in an osteoporosis fracture every 3 seconds.
  • The osteoporosis treatment gap in patients at risk of fracture in European primary care: a multi-country cross-sectional observational study.
  • Osteoporosis International, 32, pp.251-25
    Harvey, et al., 2015, Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice, Bone , Volume 78 , Pages 216-224

4 Tips to Prevent Summer Foot Pain and Injuries

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Lunedì, Giugno 19, 2023

According to foot and ankle orthopaedic surgeons, increasing your activity and time outside can also increase your risk of foot and ankle injuries.

Key Points: 
  • According to foot and ankle orthopaedic surgeons, increasing your activity and time outside can also increase your risk of foot and ankle injuries.
  • Follow these four tips to prevent pain and injuries while you stay active.
  • Foot and ankle orthopaedic surgeon Justin Tsai, MD, from Healthcare Associates in Medicine in New York, said moderation is key as people start new summer activities and hobbies.
  • Ford and Tsai recommend seeking medical attention from a foot and ankle orthopaedic surgeon in your area if you can't put weight on your foot or the pain gets worse.