Function (mathematics)

• The study also demonstrated that digital remote measurements can be used to stratify healthy subjects and patients, providing positive evidence for task validity and technical feasibility.
• We are deeply grateful to the patients, caregivers and collaborators who dedicated their time to this important first-in-class study."
• Key behavioral and EEG endpoints were evaluated cross-sectionally based on data from the first five sessions for each assessment.
• Cumulus supports precision in CNS clinical trials for its industry partners by enabling remote monitoring of patients across multiple domains of brain function.

• HTL’149 achieves this profile through selectively targeting the orphan GPR52 receptor in the brain to address positive symptoms (e.g.
• The Phase I trial is a two-part, randomized, double-blind, placebo-controlled, single- and multiple-ascending dose study to assess the safety, pharmacokinetics, and pharmacodynamics of oral HTL’149 in healthy volunteers aged 18-55 years.
• The trial will be conducted in the UK and is expected to read-out initial data in 12-18 months.
• Matt Barnes, President of Heptares Therapeutics and Head of UK R&D, said: “The progression of this wholly owned, first-in-class asset into clinical trials is a very important milestone for Sosei Heptares.

• ADHD is diagnosed using criteria from a document called DSM-5, which include symptoms of inattention, hyperactivity and impulsivity.
• But it is becoming increasingly clear to researchers that the condition also comes with self-control problems, affecting the ability to regulate emotions.
• For example, 2.1% of children with a diagnosis of ADHD also have a mood disorder, such as depression, while 27.4% have an anxiety disorder.
• Children with anxiety and depression symptoms only exhibited those deficits if they also had problems with attention.
• So it seems that one possible route to helping children with ADHD or mood disorders with cognitive development is to focus on improving their attention.

Treatments

• Methylphenidate roughly works by increasing three chemicals in the brain: dopamine, serotonin and noradrenaline.
• Dopamine can improve attention, learning, working memory and motivation, while noradrenaline reduces impulsivity and boosts attention.
• This research suggests that cognitive control, which is associated with frontal areas, can be improved by methylphenidate.
• This should be offered to children with ADHD, in conjunction with pharmacological treatments.

ADHD on the rise

• The number of ADHD diagnoses are rising across the world, and so are prescriptions of methylphenidate.
• In the UK, a study estimated that the use of ADHD medications has increased by almost 800% from 2000 to 2015.
• It may be that the prevalence of ADHD will increase even more in the future as coping strategies become less effective and people seek help and ultimately receive a diagnosis.
• The more we learn about brain basis of ADHD, the easier it will get to treat.

• BOISE, Idaho, May 31, 2023 /PRNewswire/ -- Lovevery, the global early childhood brand, today announced the expansion of its subscription early learning program with Play Kits for four-year-olds.
• Lovevery has applied their innovative approach to a fifth year of life, giving parents a holistic support system for their child as they build skills that lay a foundation of executive function.
• "The resource that we've created for four-year-olds and their parents is unmatched as the essential skill-building program for this crucial year of early learning.
• Adding a fifth year to our Play Kits program is an important step towards reaching the fullest potential of our core mission."