Autopsy

SYNAPS Dx Releases Autopsy-Confirmed Results for DISCERN™ Alzheimer’s Test and Physicians’ Assessment of Clinical Utility of DISCERN at BRAINWeek 2023

Retrieved on: 
Dienstag, September 12, 2023

AD fibroblast cells form larger aggregates in contrast to non-AD dementia (non-ADD) or non-dementia control (NDC) samples, which formed smaller and more numerous aggregates.

Key Points: 
  • AD fibroblast cells form larger aggregates in contrast to non-AD dementia (non-ADD) or non-dementia control (NDC) samples, which formed smaller and more numerous aggregates.
  • These findings were collected using a double-blind protocol for demented patients over the age of 55 and eventually confirmed through an autopsy study.
  • The clinical utility study from a sample of 402 primary care physicians (PCPs) including 250 PCPs, 102 neurologists and 50 geriatricians demonstrated that 90% physicians would routinely use the results of DISCERN.
  • While there are tests for identifying the presence of amyloid, only DISCERN has demonstrated >95% sensitivity and specificity to identify AD itself in people living with dementia or mixed dementia.

SYNAPS Dx Showcases Autopsy-Confirmed Results for DISCERN™ Alzheimer’s Test and Physicians’ Assessment of the Clinical Utility of DISCERN at BRAINWeek 2023

Retrieved on: 
Dienstag, September 5, 2023

Additionally, our poster entitled “Physicians’ Assessment of the Clinical Utility of a Novel Test to Diagnose AD” will demonstrate the important autopsy-validated clinical study of the DISCERN test and its unparalleled contribution to accurately inform physician decision-making.

Key Points: 
  • Additionally, our poster entitled “Physicians’ Assessment of the Clinical Utility of a Novel Test to Diagnose AD” will demonstrate the important autopsy-validated clinical study of the DISCERN test and its unparalleled contribution to accurately inform physician decision-making.
  • Results demonstrate that most physicians would routinely use the results of DISCERN and the test was an important attribute in physician decision-making.
  • “Our test results confirm the value of DISCERN and its positioning as a promising breakthrough for early AD diagnosis,” says Amato.
  • For more information, visit SYNAPS Dx at booth #119 at BRAINWeek 2023.

BALTIMORE COUNTY JURY AWARDS OVER $9 MILLION TO FAMILY OF PASTOR KILLED BY BEDSORE

Retrieved on: 
Montag, August 21, 2023

BALTIMORE, Aug. 21, 2023 /PRNewswire/ -- Last Thursday, a Baltimore County jury awarded $9,045,000.00 to the estate, widow, and children of Randolph Mack. The jury found that Mr. Mack died from a painful, infected pressure injury (also known as a bedsore or pressure ulcer) caused by the negligence of Stella Maris, Inc., the second-largest nursing home in Maryland. Mr. Mack's estate and family were represented by Janet, Janet & Suggs and Ketterer, Browne & Associates.

Key Points: 
  • BALTIMORE, Aug. 21, 2023 /PRNewswire/ -- Last Thursday, a Baltimore County jury awarded $9,045,000.00 to the estate, widow, and children of Randolph Mack.
  • The verdict included $8 million as compensation to Mr. Mack's estate for his pain and suffering and $1.045 million for the emotional harm suffered by the Mack family.
  • Mr. Mack was a pastor, father, and grandfather in Baltimore County.
  • An autopsy determined that Mr. Mack was killed by a severe, painful pressure injury (bedsore) near his tailbone and the resulting consequences of this injury.

Excision BioTherapeutics Announces Gene Therapy Publication of Pre-Clinical Data Supporting its First-in-Class CRISPR-Based Gene Therapy Candidate Designed to Functionally Cure HIV-1

Retrieved on: 
Donnerstag, August 17, 2023

The data support the safety, biodistribution, and on-target editing of Excision’s EBT-101 program targeting HIV, which is being evaluated in first-in-human Phase 1/2 clinical trials.

Key Points: 
  • The data support the safety, biodistribution, and on-target editing of Excision’s EBT-101 program targeting HIV, which is being evaluated in first-in-human Phase 1/2 clinical trials.
  • “We are very excited by the positive data generated in this study, which set the foundation for an important first-in-human clinical trial of our lead candidate, EBT-101,” said Daniel Dornbusch, Chief Executive Officer of Excision.
  • The newly published data supplement the efficacy data generated in previous pre-clinical studies of EBT-101, demonstrating excision of integrated proviral SIV DNA in vivo, without any detectable off-target effects.
  • “These newly published results demonstrate the tremendous potential of EBT-101 to shape the future of HIV therapeutics,” said Dr. Khalili.

What's behind our enduring fascination with wives and mothers who kill?

Retrieved on: 
Montag, August 7, 2023

Presenting herself as a concerned mother and grieving widow, she was interviewed on “Good Things Utah” in April 2023.

Key Points: 
  • Presenting herself as a concerned mother and grieving widow, she was interviewed on “Good Things Utah” in April 2023.
  • A few weeks later, on May 8, 2023, Richins was arrested and charged with killing her husband, Eric.
  • An autopsy showed that the 39-year-old man died of a massive fentanyl overdose.
  • And what occluded anxieties or longings do people confront or exorcise as they consume these stories of mayhem and murder?

‘Sleeping in a serpent’s bed’

    • It also inspired the Elizabethan domestic tragedy “Arden of Faversham” and at least one ballad.
    • The crime occurred on Valentine’s Day 1551, when Alice Arden conspired with her lover and some hired assassins to kill her husband, Thomas, at his own dinner table.
    • In 16th-century England, where the majority of adults were married, women effectively became their husbands’ legal “subjects” upon marriage.

‘Like a fierce and bloody Medea’

    • In March 2002, Yates was sentenced to life in prison, but a 2006 appeal found her not guilty by reason of insanity.
    • She now resides in a mental health facility from which she routinely refuses to apply for release.
    • Neither Vincent nor Yates had been involved in any previous crimes or scandals, but both had exhibited signs of spiritual or mental instability.
    • Yet both were excoriated in contemporary media as monsters: guilty of crimes against nature, their husbands and their offspring.
    • These events are unquestionably horrific, but the passage of two decades may have wrought some changes in the public’s response.

A queasy sort of comfort

    • The media in every period are extremely skilled at weaponizing – and capitalizing on – worries about the family’s capacity to provide a safe haven in a turbulent world.
    • In early modern England, highly gendered ideas about the home as a reflection of the state politicized anxieties about order, stability and the family as a patriarchal institution.
    • Or the appeal may lie in the idea that any of us might, in fact, be capable of such things.

UPSHER-SMITH EXPANDS VIGADRONE® (VIGABATRIN) FRANCHISE TO INCLUDE TABLETS

Retrieved on: 
Dienstag, August 1, 2023

MAPLE GROVE, Minn., July 31, 2023 /PRNewswire/ -- Upsher-Smith Laboratories, LLC (Upsher-Smith) today announced the recent launch of VIGADRONE® (vigabatrin) Tablets, USP 500 mg, a fully substitutable, AB-rated generic version of Sabril® (vigabatrin) Tablets, 500 mg.* The Company also offers VIGADRONE® (vigabatrin) for Oral Solution, USP 500 mg.

Key Points: 
  • Please see Important Safety Information, including Boxed Warning for Risk of Permanent Vision Loss at the end of this communication.
  • All people who take VIGADRONE:
    You are at risk for permanent vision loss with any amount of VIGADRONE.
  • Your risk of vision loss may be higher the more VIGADRONE you take daily and the longer you take it.
  • The most common side effects of VIGADRONE in adults include: blurred vision, sleepiness, dizziness, problems walking or feeling uncoordinated, shaking (tremor) and tiredness.

BreathMo®: The New Generation ECMO system Revealed at ASAIO Conference

Retrieved on: 
Samstag, Juli 22, 2023

Extracorporeal Membrane Oxygenation (ECMO) provides essential support for intensive care unit (ICU) patients, 60% of whom develop heart or respiratory failure with a mortality rate of 23-75%.

Key Points: 
  • Extracorporeal Membrane Oxygenation (ECMO) provides essential support for intensive care unit (ICU) patients, 60% of whom develop heart or respiratory failure with a mortality rate of 23-75%.
  • The limitation of the existing ECMO systems exposed the need for medical device manufacturers to upgrade ECMO devices equipped with advanced functions.
  • BreathMo®, China's homegrown maglev ECMO system that addresses the unmet medical needs of Chinese patients.
  • To bridge clinical gaps in China, magAssist has developed a new generation ECMO system, BreathMo®.

BreathMo®: The New Generation ECMO system Revealed at ASAIO Conference

Retrieved on: 
Freitag, Juli 21, 2023

Extracorporeal Membrane Oxygenation (ECMO) provides essential support for intensive care unit (ICU) patients, 60% of whom develop heart or respiratory failure with a mortality rate of 23-75%.

Key Points: 
  • Extracorporeal Membrane Oxygenation (ECMO) provides essential support for intensive care unit (ICU) patients, 60% of whom develop heart or respiratory failure with a mortality rate of 23-75%.
  • The limitation of the existing ECMO systems exposed the need for medical device manufacturers to upgrade ECMO devices equipped with advanced functions.
  • BreathMo®, China's homegrown maglev ECMO system that addresses the unmet medical needs of Chinese patients.
  • To bridge clinical gaps in China, magAssist has developed a new generation ECMO system, BreathMo®.

SYNAPS Dx DISCERN™ Test Provides Accurate Diagnosis of Alzheimer’s Disease, Optimizes Prescribing, Minimizes Patient Risks and Informs Coverage Decisions for Leqembi™

Retrieved on: 
Dienstag, Juli 11, 2023

Pursuant to the Leqembi label , once AD is identified, then an assessment of amyloid positivity can be performed in determining if the drug is appropriate.

Key Points: 
  • Pursuant to the Leqembi label , once AD is identified, then an assessment of amyloid positivity can be performed in determining if the drug is appropriate.
  • In clinical utility studies, clinicians were four times more likely to prescribe drugs like Leqembi with a positive DISCERN test than if the test was negative.
  • The established relationship between AD and the skin provides unique positioning for DISCERN which requires a minimally invasive, 3mm skin punch biopsy .
  • “AD is complex but DISCERN resolves the diagnostic dilemma , enabling physicians to make a more definitive diagnosis,” continues Amato.

How Deadloch flips the Nordic Noir crime genre on its arse and makes it funny

Retrieved on: 
Donnerstag, Juni 29, 2023

Clearly someone is going to die, if they are not already dead, and a small community will be riven as its dark secrets are exposed to the pale light of a wintry Nordic day.

Key Points: 
  • Clearly someone is going to die, if they are not already dead, and a small community will be riven as its dark secrets are exposed to the pale light of a wintry Nordic day.
  • This is Deadloch, the fictional town that is the setting for a comedy crime drama that flips the Nordic Noir genre on its arse, so to speak.

Funny Broadchurch

    • In 2015, they launched The Katering Show on YouTube: a web series spoofing the homely genre of the cooking show that eventually found its way onto ABC iview.
    • They followed it with Get Krack!n, an attack on the genre of the cheerful but inane television breakfast show.
    • Apparently, the inspiration emerged from the “explosion of Nordic Noir” they were watching while breastfeeding at in the early mornings of 2015.

What is Nordic Noir anyway?

    • The impact of Nordic Noir on television production around the world has indeed been significant.
    • While there are those who suggest Nordic Noir may have already passed its use by date, McCulloch and Proctor argue that the ripple effects are still being felt.

Australian Noir

    • Australian crime dramas with clear Nordic Noir influences have become common.
    • Produced by Matchbox pictures for Foxtel Showcase in 2016, Secret City re-imagined Canberra as the sexy setting for a Nordic Noir drama that owed as much to the Danish series Borgen as it did to The Bridge in terms of its aesthetics and style.
    • The politics, however, were resolutely Australian, featuring Australia’s pig-in-the-middle predicament in the US-China power game.

Flip the colour palette

    • The ABC Indigenous crime drama Mystery Road flipped the colour palette to orange and red in what Bunya Productions producer David Jowsey described as “tropical outback gothic noir”.
    • Mystery Road managed to retain the measured pace of Nordic Noir and exquisite attention to a monumental and threatened landscape, while focusing on Indigenous issues.

Potty-mouthed satire

    • Which brings us back to Deadloch and the apotheosis of the Australian assimilation of Nordic Noir as a potty-mouthed satire that is also a feisty feminist take on the more usual gender politics of the crime drama.
    • Instead of a mismatched male and female cop from different cultural backgrounds, we have a couple of mismatched female detectives whose initially testy relationship gradually ameliorates as they join forces in the quest for the truth.
    • Rather than a married male detective having problems at home, we have a female detective whose lesbian wife needs constant affirmation.